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June 04, 2009


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Hello Arvin,

Wish you a Merry Xmas and Happy New Year!!!

1H NMR of my compound does not show NH2 peak and the NMR was taken in CDCL3. What could be the reason for the non appearance of NH2 peak? Are there any experiments to show the existence of NH2 peak? Mass spec/1H NMR corresponds to the structure.

Thanks for the help.


Adolph Bohnstedt

What relative effect does H-bonding vs acidity have on the speed of proton exchange? My guess would be that H-bonding is more critical since an amide NH will exchange quite rapidly in a D2O shake, but would you expect the more acidic alpha-protons in a beta-diketone to exchange as readily?

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