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Diastereotopic protons that are also anisochronous exhibit different chemical shifts. As a general rule, the proximity of a chiral centre will influence the likelihood of diastereotopic proton signals being anisochronous.
For the structure below, the CH2 labeled A is most likely to be anisochronous due to the adjacent chiral carbon.
IUPAC: methyl 7-hydroxy-3,5-dioxo-7-phenylheptanoate
InChi Key: FOGURBALCWIVHU-UHFFFAOYSA-N
A thanks goes to Carlos for submitting a comment.
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Arvin.
Have you wrote some topic about virtual coupling?
Djalma
Posted by: Djalma de Oliveira | May 30, 2012 at 04:33 PM