LC/MS has become the primary analytical check for the medicinal chemist. I Love NMR, but it's the reality
More often than not, NMR spectra are merely glanced at:
- Sometimes interpretation is based on the presence or absence of one peak (did my reaction go to completion?)
- How often are NMR spectra fully assigned by a medicinal/synthetic chemist? Not very often, it's not their job.
- Is all the information a 1H NMR spectrum can provide being effectively used? Some chemists are extremely good at NMR, other couldn't be bothered with the intimate details, and I can't say I blame them. It's largely a training/education issue
- How often are 2-dimensional experiments acquired and interpreted? Of course this varies chemist by chemists, organization..but despite strong advances in hardware, acquisition, etc, I believe the safe answer is, "not enough"
In many organizations, upwards of 95% of compounds are being registered by synthetic/medicinal chemists without having undergone any analytical review by an analytical specialist (NMR spectroscopist).
How and why did we get here? I have some hypotheses, and will write about them in the coming days.